T cells are derived from haematopoietic stem cells that are found in the bone marrow. The progenitors of these cells migrate to and colonise the thymus. The developing progenitors within the thymus, also known as thymocytes, undergo a series of maturation steps that can be identified based on the expression of different cell surface markers. Developing thymocytes interact with the thymus stromal non-haematopoietic cells, and undergo the process described below in distinct regions of the thymus. The thymus is made up of an outer cortex and an inner medulla region. The earliest developing thymocytes lack the expression of the co-receptors CD4 and CD8 and are termed double negative DN cells.
When the body is invaded by bacteria, a virus or parasites, an immune alarm goes off, setting off a chain reaction of cellular activity in the immune system. Macrophages or other innate immune cells, such as basophils, dendritic cells or neutrophils, may be deployed to help attack the invading pathogen.
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A T cell, or T lymphocyte, is a type of lymphocyte that plays a central...
Generation of lymphocytes in bone marrow and thymus - Immunobiology...
The stages in primary B-cell to become mature B cells that. T cells are derived from haematopoietic stem cells...
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THE T CELL: T-CELLS MATURE IN THE THYMUS GLAND OR IN THE LYMPH NODES. SINCE THE THYMUS IS ONLY...
T CELLS MATURE IN
AT EXHIBIT, WE KEEP A PLANE WHICH COULD TENTATIVELY TRIAL...
Immunobiology: The Immune System in Health and Disease. 5th edition.
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