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There are significant inter-individual differences in the levels of gene expression. Through modulation of gene expression, cis -acting variants represent an important source of phenotypic variation. Consequently, c is -regulatory SNPs associated with differential allelic expression are functional candidates for further investigation as disease-causing variants. Thereafter, using data from a genome-wide map of allelic expression associated SNPs, genetic variants were selected and their association with breast cancer risk was then evaluated in 46, breast cancer cases and 42, controls of European ancestry ascertained from 41 studies participating in the Breast Cancer Association Consortium. The associations were evaluated with overall breast cancer risk and with estrogen receptor negative and positive disease. Breast cancer is a complex disease with a strong heritable component. Great efforts have been made during the last decades to elucidate the underlying etiology of this disease.

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Author information: We report two cases of recurrent breast cancer with regional lymph node metastases that responded completely to treatment with trastuzumab and paclitaxel. Case 1: A year-old woman, who presented with left breast cancer, underwent mastectomy and axillary lymph node dissection in July

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